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Expression levels of the putative zinc transporter LIV-1 are associated with a better outcome of breast cancer patients.

Abstract
We investigated the expression pattern of the breast cancer associated gene LIV-1 on mRNA and protein level in 111 human breast cancer patients by in situ hybridization as well as immunohistochemistry and focused on the unknown potential of LIV-1 expression levels as a prognostic marker. To our knowledge, this is the first study on endogenous LIV-1 protein expression. Results of our study indicate that LIV-1 mRNA and protein expression levels are only weakly correlated, suggesting posttranscriptional regulatory mechanisms. Furthermore, LIV-1 mRNA quantity in combination with a positive ER status seem to represent a better marker than the progesterone receptor status according to the prognostic significance for relapse free survival (RFS). A negative correlation of LIV-1 protein levels with tumor size, grade and stage reflects an association of LIV-1 protein expression with less aggressive tumors. High LIV-1 protein expression seems to be associated with a longer relapse free and overall survival in breast cancer patients with invasive ductal carcinoma. This association, however, seems to be dependent from other prognostic markers. Our data suggest that LIV-1 is a promising candidate for a novel marker for breast cancer patients with better outcome. Furthermore, our study presents a revised cDNA sequence of LIV-1 and demonstrates the localization of endogenous LIV-1 in the endoplasmic reticulum.
AuthorsGrit Kasper, Armin A Weiser, Andreas Rump, Katrin Sparbier, Edgar Dahl, Arndt Hartmann, Peter Wild, Uta Schwidetzky, Esmeralda Castaños-Vélez, Kerstin Lehmann
JournalInternational journal of cancer (Int J Cancer) Vol. 117 Issue 6 Pg. 961-73 (Dec 20 2005) ISSN: 0020-7136 [Print] United States
PMID15986450 (Publication Type: Journal Article)
CopyrightCopyright 2005 Wiley-Liss, Inc
Chemical References
  • Cation Transport Proteins
  • DNA, Complementary
  • Neoplasm Proteins
  • RNA, Messenger
  • Receptors, Estrogen
  • SLC39A6 protein, human
  • Tamoxifen
Topics
  • Base Sequence
  • Breast Neoplasms (chemistry, genetics, pathology)
  • Cation Transport Proteins (analysis, genetics)
  • DNA, Complementary (chemistry)
  • Disease-Free Survival
  • Drug Resistance, Neoplasm
  • Endoplasmic Reticulum (chemistry)
  • Gene Expression
  • Humans
  • Immunohistochemistry
  • In Situ Hybridization
  • Middle Aged
  • Molecular Sequence Data
  • Neoplasm Proteins (analysis, genetics)
  • Neoplasm Recurrence, Local
  • Prognosis
  • RNA, Messenger (analysis)
  • Receptors, Estrogen (analysis)
  • Survival Rate
  • Tamoxifen

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