Abstract | BACKGROUND AND OBJECTIVE: Data from a randomized trial in hepatitis C infected Egyptian patients suggest that the oral intake of the enzyme preparation Phlogenzym results in a significant reduction of aminotransferase levels and is equally effective to the therapy with interferon alpha. In our study, we investigated whether comparable effects can be found in daily practice in German patients. PATIENTS AND METHODS: RESULTS: 22 patients were included into the analyses. The mean duration of treatment with Phlogenzym was 77 +/- 41 days. ALT, aspartate-aminotransferase (AST) and gamma glutamyl transpeptidase (GGT) levels did not change significantly during treatment. Fitting a generalized linear model, we estimated that a hypothetical patient who started with a baseline value of 50 U/I after 90 days of treatment ends up in an ALT level of 52 U/I (95%-CI:27-77 U/I), an AST level of 51 U/I (35-67 U/I) and a GGT level of 42 U/I (22-61 U/I). 5 out of 22 patients had to stop treatment because of side effects. CONCLUSION:
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Authors | Roman Huber, Isabel Futter, Roland Goedl, Matthias Rostock, Rainer Lüdtke |
Journal | Forschende Komplementarmedizin und klassische Naturheilkunde = Research in complementary and natural classical medicine
(Forsch Komplementarmed Klass Naturheilkd)
Vol. 12
Issue 3
Pg. 144-7
(Jun 2005)
ISSN: 1424-7364 [Print] Switzerland |
Vernacular Title | Orale Enzymtherapie bei chronischer Hepatitis C -- eine retrospektive Analyse. |
PMID | 15985778
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Drug Combinations
- Phlogenzym
- Rutin
- Bromelains
- gamma-Glutamyltransferase
- Aspartate Aminotransferases
- Trypsin
|
Topics |
- Administration, Oral
- Aspartate Aminotransferases
(blood)
- Bromelains
(administration & dosage, therapeutic use)
- Complementary Therapies
- Drug Combinations
- Hepatitis C
(blood, drug therapy, enzymology)
- Humans
- Retrospective Studies
- Rutin
(administration & dosage, analogs & derivatives, therapeutic use)
- Trypsin
(administration & dosage, therapeutic use)
- gamma-Glutamyltransferase
(blood)
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