Abstract |
A 46-year-old man was admitted to our hospital with swelling of a neck lymph node in June, 2002, and was diagnosed with adult T-cell leukemia/lymphoma ( ATLL). As ATLL cells were detected in the peripheral blood after two courses of multi-agent chemotherapy (LSG 15), the treatment was changed to biweekly CHOP therapy. After two courses, hematological remission was achieved. Allogeneic bone marrow transplant (allo-BMT) from HTLV- negative and HLA-matched sibling donor was performed (conditioned with cyclophosphamide 60 mg/kg x 2 and total body irradiation 12 Gy). Cyclosporine A (CsA) and short-term methotrexate (MTX) were used for graft-versus-host disease prevention. Though the HTLV- provirus DNA (Southern blot) disappeared, HTLV-I provirus DNA (real-time PCR) T-cell receptor ygammachain gene rearrangement DNA (Southern blot) were detected in bone marrow after allo-BMT. MRD disappeared after the withdrawal of CsA. After the allo-BMT transplant, a graft-versus- ATLL (GVATLL) effect may be induced by abrupt discontinuation of immunosuppression.
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Authors | Satoshi Hara, Taiji Yokote, Tomokazu Akioka, Satoshi Oka, Tsuyoshi Yamano, Motomu Tsuji, Toshiaki Hanafusa |
Journal | Gan to kagaku ryoho. Cancer & chemotherapy
(Gan To Kagaku Ryoho)
Vol. 32
Issue 6
Pg. 867-71
(Jun 2005)
ISSN: 0385-0684 [Print] Japan |
PMID | 15984534
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- DNA, Viral
- Vincristine
- Doxorubicin
- Cyclosporine
- Cyclophosphamide
- Prednisone
- Methotrexate
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Topics |
- Antineoplastic Combined Chemotherapy Protocols
(administration & dosage, therapeutic use)
- Bone Marrow Transplantation
- Cyclophosphamide
(administration & dosage)
- Cyclosporine
(administration & dosage)
- DNA, Viral
(analysis)
- Doxorubicin
(administration & dosage)
- Graft vs Leukemia Effect
- Human T-lymphotropic virus 1
(genetics)
- Humans
- Immunosuppression Therapy
- Leukemia-Lymphoma, Adult T-Cell
(drug therapy, pathology, therapy)
- Male
- Methotrexate
(administration & dosage)
- Middle Aged
- Neoplasm, Residual
- Prednisone
(administration & dosage)
- Remission Induction
- Vincristine
(administration & dosage)
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