Abstract | OBJECTIVE: RESEARCH DESIGN AND METHODS: This was a single-center, uncontrolled, open-label study investigating the effects of 8 weeks of raloxifene (60 mg/day) therapy on plasma lipids. The study subjects were 12 postmenopausal women, ages 49-73 years, with a documented history of oral estrogen-induced hypertriglyceridemia (serum triglycerides > or =3.39 mmol/l [> or =300 mg/dl]). RESULTS: At week 2 of the study, three (25%) of the subjects withdrew from the trial because they developed marked hypertriglyceridemia (>or =11.3 mmol/l [> or =1,000 mg/dl]) during raloxifene therapy. These three women had higher baseline triglyceride and glucose levels, were not being treated with lipid-lowering agents, and were more likely to have diabetes than the other study subjects. The remaining nine patients (75%) completed the 8-week trial and experienced a nonsignificant increase in mean triglyceride levels from baseline to end point. Raloxifene treatment also resulted in a significant 16% decrease in hepatic lipase activity and a 26% increase in HDL(2) levels (P = 0.013 and 0.03, respectively). CONCLUSIONS:
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Authors | Molly C Carr, Robert H Knopp, John D Brunzell, Barbara S Wheeler, Xiaodong Zhu, Mark Lakshmanan, Amy S Rosen, Pamela W Anderson |
Journal | Diabetes care
(Diabetes Care)
Vol. 28
Issue 7
Pg. 1555-61
(Jul 2005)
ISSN: 0149-5992 [Print] United States |
PMID | 15983300
(Publication Type: Clinical Trial, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Apolipoproteins
- Lipoproteins
- Selective Estrogen Receptor Modulators
- Triglycerides
- Raloxifene Hydrochloride
- Cholesterol
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Topics |
- Aged
- Apolipoproteins
(blood)
- Cholesterol
(blood)
- Estrogen Replacement Therapy
- Female
- Humans
- Hypertriglyceridemia
(blood)
- Lipoproteins
(blood)
- Middle Aged
- Patient Compliance
- Postmenopause
- Raloxifene Hydrochloride
(therapeutic use)
- Selective Estrogen Receptor Modulators
(therapeutic use)
- Triglycerides
(blood)
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