Osteomalacia due to chemotherapy-induced Fanconi syndrome in an adult patient.

Abstract

BACKGROUND:

Chemotherapy-induced Fanconi syndrome is a dangerous condition that could lead to severe electrolyte disturbances and rarely to osteomalacia.

CASE:

A patient treated with ifosfamide for a metastatic cervix squamous-cell carcinoma was admitted for diffuse, symmetric bilateral pain in bones and articulations. The diagnosis work-up revealed that she suffered from osteomalacia due to a chemotherapy-induced Fanconi syndrome. The patient recovered completely with oral calcitriol supplements.

CONCLUSIONS:

This very rare chemotherapy-complication suggests that detection of potential tubular dysfunction, by regular serum electrolyte monitoring of patients receiving ifosfamide, may be a reasonable approach to diagnose early chemotherapy-induced Fanconi syndrome, even in adults.

• Authors: Lionel Duck, Jean-Pierre Devogelaer, Alexandre Persu, Martine Berlière, Emmanuelle Caussin, Jean-François Baurain, Jean-Pascal Machiels
• Journal: Gynecologic oncology (Gynecol Oncol) Vol. 98 Issue 2 Pg. 329-31 (Aug 2005) ISSN: 0090-8258 [Print] United States
• PMID: 15975640 (Publication Type: Case Reports, Journal Article)

Chemical References

• Ifosfamide

Topics

• Carcinoma, Squamous Cell (drug therapy)
• Fanconi Syndrome (chemically induced, complications)
• Female
• Humans
• Ifosfamide (adverse effects, therapeutic use)
• Middle Aged
• Osteomalacia (etiology)
• Uterine Cervical Neoplasms (drug therapy)