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New insights into serotonin 5-HT4 receptors : a novel therapeutic target for Alzheimer's disease?

Abstract
The serotonin 5-HT4 receptor mediates many physiological effects in the central nervous system. The recent molecular identification of 5-HT4 receptors and the development of selective 5-HT4 receptor ligands have led to many important new insights into the signalling pathways and the physiological roles of these G protein-coupled-receptors in neurones. With respect to neurodegenerative disorders, it is suggested that 5-HT4 agonists may represent a new avenue for the treatment of Alzheimer's disease. This mini-review will focus on recent in vitro and in vivo pharmacological and biochemical studies showing the involvement of 5-HT4 receptors in cognitive processes and the amyloid precursor protein processing. The potential use of 5-HT4 agonists for the treatment of AD will be discussed.
AuthorsMarjorie Maillet, Sylvain J Robert, Frank Lezoualc'h
JournalCurrent Alzheimer research (Curr Alzheimer Res) Vol. 1 Issue 2 Pg. 79-85 (May 2004) ISSN: 1567-2050 [Print] United Arab Emirates
PMID15975071 (Publication Type: Journal Article, Review)
Chemical References
  • Amyloid beta-Protein Precursor
  • Serotonin Receptor Agonists
  • Receptors, Serotonin, 5-HT4
Topics
  • Alzheimer Disease (drug therapy, metabolism, psychology)
  • Amyloid beta-Protein Precursor (metabolism)
  • Animals
  • Cognition
  • Humans
  • Protein Processing, Post-Translational
  • Receptors, Serotonin, 5-HT4 (metabolism)
  • Serotonin Receptor Agonists (therapeutic use)

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