Synthesis, analgesic, and anti-inflammatory activities of [6-(3,5-dimethyl-4-chloropyrazole-1-yl)-3(2H)-pyridazinon-2-yl]acetamides.

Abstract

A series of structurally diverse amide derivatives of [6-(3,5-dimethyl-4-chloro-pyrazole-1-yl)-3(2H)-pyridazinone-2-yl]acetic acid were prepared and tested for their in vivo analgesic and anti-inflammatory activity by using p-benzoquinone-induced writhing test and carrageenan-induced hind paw edema model, respectively. The analgesic and anti-inflammatory activity of the compounds, 7c, 7d and 7k were found to be equipotent to aspirin (as an analgesic) and indometacin (as an anti-inflammatory drug), respectively. The other amide derivatives generally resulted in lower activity on comparision with reference compounds.

• Authors: Murat Süküroglu, Burcu Caliskan Ergün, Serdar Unlü, M Fethi Sahin, Esra Küpeli, Erdem Yesilada, Erden Banoglu
• Journal: Archives of pharmacal research (Arch Pharm Res) Vol. 28 Issue 5 Pg. 509-17 (May 2005) ISSN: 0253-6269 [Print] Korea (South)
• PMID: 15974435 (Publication Type: Journal Article)

Chemical References

• Acetamides
• Analgesics
• Anti-Inflammatory Agents
• Pyrazoles
• Pyridazines

Topics

• Acetamides (chemical synthesis, pharmacology)
• Analgesics (chemical synthesis, pharmacology)
• Animals
• Anti-Inflammatory Agents (chemical synthesis, pharmacology)
• Mice
• Pyrazoles (chemical synthesis, pharmacology)
• Pyridazines (chemical synthesis, pharmacology)