Effect of tamoxifen in an experimental model of breast tumor studied by dynamic contrast-enhanced magnetic resonance imaging and different contrast agents.

Abstract

OBJECTIVES:

The aim of this study was to compare the efficacy of gadoteridol, B22956/1 (a new protein binding blood pool contrast agent), and (Gd-DTPA)37-albumin in detecting, by dynamic contrast-enhanced magnetic resonance imaging (MRI), the effect in vivo of tamoxifen in an experimental model of breast tumor implanted in rats.

MATERIALS AND METHODS:

Tumors were induced by subcutaneous injection of 10 mammary adenocarcinoma cells (13762 MAT B III). Treatment with tamoxifen (or vehicle) started on day 4 after implantation. On day 10 after implantation, animals were observed by MRI using B22956/1 (or gadoteridol) and, 24 hours later, using (Gd-DTPA)37-albumin.

RESULTS:

Dynamic contrast-enhanced magnetic resonance imaging data showed that tamoxifen treatment decreased vascular permeability to B22956/1, whereas no difference was detectable in permeability to gadoteridol or to (Gd-DTPA)37-albumin. No effect on fractional plasma volume was detected with either of contrast agents.

CONCLUSIONS:

B22956/1 is superior to both small Gd chelates and macromolecular contrast agents in the assessment of the effect of tamoxifen treatment on tumor vasculature.

• Authors: Pasquina Marzola, Simona Ramponi, Elena Nicolato, Emanuela Lovati, Marco Sandri, Laura Calderan, Caterina Crescimanno, Flavia Merigo, Andrea Sbarbati, Adriana Grotti, Stefania Vultaggio, Friederich Cavagna, Vito Lorusso, Francesco Osculati
• Journal: Investigative radiology (Invest Radiol) Vol. 40 Issue 7 Pg. 421-9 (Jul 2005) ISSN: 0020-9996 [Print] United States
• PMID: 15973133 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Albumins
• Angiogenesis Inhibitors
• Contrast Media
• Estrogen Antagonists
• Heterocyclic Compounds
• Organometallic Compounds
• gadoteridol
• Tamoxifen
• Gadolinium
• Gadolinium DTPA

Topics

• Albumins
• Angiogenesis Inhibitors (pharmacology)
• Animals
• Breast Neoplasms (blood supply, drug therapy)
• Contrast Media
• Estrogen Antagonists (pharmacology, therapeutic use)
• Female
• Gadolinium
• Gadolinium DTPA
• Heterocyclic Compounds
• Image Enhancement
• Image Processing, Computer-Assisted
• Magnetic Resonance Imaging (methods)
• Mammary Neoplasms, Experimental
• Organometallic Compounds
• Rats
• Tamoxifen (pharmacology, therapeutic use)