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Role of motility and flagellin glycosylation in the pathogenesis of Pseudomonas aeruginosa burn wound infections.

Abstract
In this study, we tested the contribution of flagellar motility, flagellin structure, and its glycosylation in Pseudomonas aeruginosa using genetically defined flagellar mutants. All mutants and their parent strains were tested in a burned-mouse model of infection. Motility and glycosylation of the flagellum appear to be important determinants of flagellar-mediated virulence in this model. This is the first report where genetically defined flagellar variants of P. aeruginosa were tested in the burned-mouse model of infection.
AuthorsShiwani K Arora, Alice N Neely, Barbara Blair, Stephen Lory, Reuben Ramphal
JournalInfection and immunity (Infect Immun) Vol. 73 Issue 7 Pg. 4395-8 (Jul 2005) ISSN: 0019-9567 [Print] United States
PMID15972536 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Flagellin
Topics
  • Animals
  • Burns (complications)
  • Flagellin (chemistry, metabolism)
  • Glycosylation
  • Lethal Dose 50
  • Mice
  • Movement
  • Pseudomonas Infections (etiology)
  • Pseudomonas aeruginosa (pathogenicity)
  • Wound Infection (etiology)

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