Abstract | OBJECTIVES: To clarify the initial onset time of osteonecrosis after the start of steroid treatment and its relation to the onset of abnormal lipid metabolism. METHODS: RESULTS: A single, acute ischaemic event suggested by the frequency, size or number of necrotic foci within the proximal femur was not different among the groups. Histological evidence of osteonecrosis first occurred 1-2 weeks after initial steroid administration. At the same time there were significantly abnormal elevations in serum lipids, which persisted for between 1 and 2 weeks after the initial corticoid treatment. Triglycerides, total cholesterol and free fatty acids were markedly elevated in all groups; these lipid abnormalities were significantly present in the rabbits with osteonecrosis but not in the rabbits without osteonecrosis. CONCLUSIONS:
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Authors | T Kabata, T Kubo, T Matsumoto, T Hirata, M Fujioka, K A Takahashi, S Yagishita, M Kobayashi, K Tomita |
Journal | Rheumatology (Oxford, England)
(Rheumatology (Oxford))
Vol. 44
Issue 10
Pg. 1233-7
(Oct 2005)
ISSN: 1462-0324 [Print] England |
PMID | 15972352
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Fatty Acids, Nonesterified
- Glucocorticoids
- Methylprednisolone
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Topics |
- Animals
- Disease Models, Animal
- Fatty Acids, Nonesterified
(blood)
- Female
- Glucocorticoids
(adverse effects)
- Hyperlipidemias
(chemically induced, complications)
- Methylprednisolone
(adverse effects)
- Osteonecrosis
(blood, chemically induced, etiology, pathology)
- Rabbits
- Time Factors
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