Abstract | OBJECTIVE: METHODS: Seven patients with SLE and skin involvement (including acute cutaneous lupus, subacute cutaneous lupus, discoid lupus erythematosus, vasculitis, urticarial rash and chilblain lupus) who had received treatment with MMF were included. The clinical characteristics, serologicalfindings and response to treatment were recalledfrom retrospective review of the files. RESULTS: Our results showed no response in 5 patients, partial response in 1 patient and initial response but skin flare whilst on MMF in 1 patient. The median dose of MMF was 2 g (range 2-3 g). Adverse events on MMF were mild, mainly gastrointestinal and occurred in 5 patients. No patients discontinued MMF due to adverse events. CONCLUSIONS: MMF appears not to be particularly effective in the treatment of skin disease in SLE. It should be noted that our group of patients had previously failed to respond to a median of 4 (range 2-10) different drugs used to treat SLE skin disease. Thus, the patients in the study could be considered at the severe end of skin disease spectrum.
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Authors | C N Pisoni, G Obermoser, M J Cuadrado, F J Sanchez, Y Karim, N T Sepp, M A Khamashta, G R V Hughes |
Journal | Clinical and experimental rheumatology
(Clin Exp Rheumatol)
2005 May-Jun
Vol. 23
Issue 3
Pg. 393-6
ISSN: 0392-856X [Print] Italy |
PMID | 15971430
(Publication Type: Journal Article)
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Chemical References |
- Dermatologic Agents
- Mycophenolic Acid
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Topics |
- Adolescent
- Adult
- Dermatologic Agents
(therapeutic use)
- Female
- Humans
- Lupus Erythematosus, Cutaneous
(drug therapy, pathology)
- Male
- Middle Aged
- Mycophenolic Acid
(analogs & derivatives, therapeutic use)
- Retrospective Studies
- Treatment Failure
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