Abstract | BACKGROUND AND METHODS: RESULTS: As compared with the dogs that received phorbol myristate acetate alone, the edematous lung damage was significantly reduced in those dogs that received dimethylthiourea as well as phorbol myristate acetate. In the dimethylthiourea-treated dogs, the lung wet/dry weight ratios were smaller (p less than .01); protein concentrations in lung lavage fluid were lower (p less than .01); the decrease in PaO2 was significantly reduced (p less than .01); and there were significant reductions in the alveolar-arterial oxygen tension difference (P[A-a]O2) (p less than .01) and shunt (Qsp/Qt) (p less than .05). Also, dimethylthiourea significantly lowered the increased mean pulmonary arterial pressure levels during the second half of the experiment. CONCLUSIONS:
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Authors | K Hsu, D Wang, M H Li, C H Chiang, C Y Shen |
Journal | Critical care medicine
(Crit Care Med)
Vol. 20
Issue 6
Pg. 823-30
(Jun 1992)
ISSN: 0090-3493 [Print] United States |
PMID | 1597038
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- 1,3-dimethylthiourea
- Thiourea
- Tetradecanoylphorbol Acetate
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Topics |
- Acute Disease
- Animals
- Blood Gas Analysis
- Dogs
- Drug Evaluation, Preclinical
- Female
- Hemodynamics
(drug effects, physiology)
- Lung
(drug effects, physiopathology)
- Male
- Pulmonary Edema
(chemically induced, drug therapy, physiopathology)
- Random Allocation
- Tetradecanoylphorbol Acetate
(toxicity)
- Thiourea
(analogs & derivatives, therapeutic use)
- Time Factors
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