Antitumor activity of a novel nucleoside, 2'-C-cyano-2'-deoxy-1-beta-D-arabinofuranosylcytosine (CNDAC) against murine and human tumors.

Abstract

The antitumor effects of 2'-C-cyano-2'-deoxy-1-beta-D- arabinofuranosylcytosine (CN-DAC), a synthetic 1-beta-D-arabinofuranosyl-cytosine (ara-C) derivative, were examined and compared with that of ara-C in murine tumors and in various human tumors using three different chemosensitivity tests. CNDAC extended the life span of mice bearing P388 leukemia. CNDAC had a unique in vitro antitumor spectrum for human cancers different from that of ara-C. Compared with ara-C, CNDAC was more effective in 10 human tumors (2 lung, 4 stomach and 4 osteosarcoma), equal in 2 tumors (lung and fibrosarcoma) and less potent in 11 tumors (4 lung, 4 osteosarcoma, bladder, renal and epidermoid). Characteristically CNDAC showed excellent activities against tumors, refractory to ara-C, such as HT-1080 human fibrosarcoma implanted in chick embryos or athymic mice, although its cytotoxicity against HT-1080 was almost equal to that of ara-C. Thus, CNDAC is an interesting and promising agent that should be considered for further detailed preclinical evaluation.

• Authors: M Tanaka, A Matsuda, T Terao, T Sasaki
• Journal: Cancer letters (Cancer Lett) Vol. 64 Issue 1 Pg. 67-74 (May 30 1992) ISSN: 0304-3835 [Print] Ireland
• PMID: 1596880 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Cytarabine
• 2'-cyano-2'-deoxyarabinofuranosylcytosine
• Cytidine Deaminase

Topics

• Animals
• Antineoplastic Agents (pharmacology)
• Cell Survival (drug effects)
• Chick Embryo
• Cytarabine (analogs & derivatives, pharmacology, therapeutic use)
• Cytidine Deaminase (metabolism)
• Humans
• Leukemia P388 (drug therapy)
• Mice
• Mice, Nude
• Tumor Cells, Cultured (drug effects, metabolism)