Photodynamic activity of dibiotinylated aluminum sulfophthalocyanine in vitro and in vivo.

Abstract

The photodynamic activity of dibiotinylated aluminum sulfophthalocyanine was studied in vitro and in vivo. Dibiotinylated aluminum sulfophthalocyanine provided enhanced phototoxic action on OAT-75 cell monolayers as compared with the parent drug. Photodynamic therapy of mice with Ehrlich carcinoma using dibiotinylated aluminum sulfophthalocyanine (0.25 mg/kg) resulted in enhanced inhibition of tumor growth, pronounced vascular damage (thrombosis and destruction of vascular walls) and eventual tumor necrosis.

• Authors: Irina G Meerovich, Victoriav Jerdeva, Valentina M Derkacheva, Gennady A Meerovich, Eugeny A Lukyanets, Eugenia A Kogan, Alexander P Savitsky
• Journal: Journal of photochemistry and photobiology. B, Biology (J Photochem Photobiol B) Vol. 80 Issue 1 Pg. 57-64 (Jul 01 2005) ISSN: 1011-1344 [Print] Switzerland
• PMID: 15963437 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Indoles
• Photosensitizing Agents
• dibiotinylated aluminum sulfophthalocyanine
• Biotin
• Aluminum

Topics

• Aluminum (pharmacology, radiation effects)
• Animals
• Biotin (analogs & derivatives, chemical synthesis, pharmacology)
• Biotinylation
• Carcinoma, Small Cell
• Cell Line, Tumor
• Cell Survival (drug effects, radiation effects)
• Humans
• Indoles (chemical synthesis, pharmacology)
• Light
• Lung Neoplasms
• Mice
• Photochemotherapy
• Photosensitizing Agents (chemical synthesis, pharmacology)