Abstract | OBJECTIVE: MATERIALS AND METHODS:
Ethylene glycol (EG) was administered at 150 mg/day by gavage for 3 weeks to rats fed on diets with adequate (group 1), excess (group 2) or deficient (group 3) vitamin E. Several indicators of peroxidation, free radicals and enzymatic activity were then assessed. RESULTS: EG treatment in group 1 lead to increased lipid peroxidation, protein thiol, excretion of urinary enzymes, oxalate and decreases in urinary calcium, antioxidant enzymes and altered glutathione redox balance. Although renal function was not altered, there was increased water intake, urine volume and lowered urinary pH in these rats. These changes were more intense, with extensive calcium-oxalate crystal deposition, in rats in group 3, and prevented in rats in group 2, except for urinary oxalate levels, which remained high. Histopathological examination showed that there was no deposition of calcium oxalate crystals in rats in group 2. CONCLUSION:
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Authors | Sivagnanam Thamilselvan, Mani Menon |
Journal | BJU international
(BJU Int)
Vol. 96
Issue 1
Pg. 117-26
(Jul 2005)
ISSN: 1464-4096 [Print] England |
PMID | 15963133
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Antioxidants
- Vitamin E
- Calcium Oxalate
|
Topics |
- Animals
- Antioxidants
(therapeutic use)
- Calcium Oxalate
(metabolism)
- Crystallization
- Hyperoxaluria
(prevention & control)
- Kidney Calculi
(chemistry, prevention & control)
- Male
- Models, Animal
- Rats
- Rats, Sprague-Dawley
- Vitamin E
(therapeutic use)
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