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Efficacy of benzimidazole carbamate on an intestinal fluke co-infected with nematodes.

Abstract
The efficacy of a single dose of benzimidazole, drugs commonly used for the treatment of Ascaris and hookworm, was evaluated against one of the tiny-sized intestinal flukes, Haplorchis sp in the endemic area where mixed infections of roundworms and flatworms existed. At day 7 after treatment, albendazole (400 mg) induced 42.5% cure rate, mebendazole (500 mg) a cure rate of 32.4%, on the other hand, praziquantel (40 mg/kg) gave 94.6% cure rate and the placebo at 15.9%. At the single dose, benzimidazole could not completely expelled the haplorchid; but could reduce one third to two fifth of the infection, similar to the drugs efficacy against Trichuris infection.
AuthorsJitra Waikagul, Dorn Watthanakulpanich, Chatree Muennoo, Wanna Maipanich, Surapol Sa-nguankiat, Somchit Phubampen
JournalJournal of the Medical Association of Thailand = Chotmaihet thangphaet (J Med Assoc Thai) Vol. 88 Issue 2 Pg. 233-7 (Feb 2005) ISSN: 0125-2208 [Print] Thailand
PMID15962676 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Anthelmintics
  • Benzimidazoles
  • Praziquantel
  • Mebendazole
  • benzimidazole
  • Albendazole
Topics
  • Albendazole (therapeutic use)
  • Anthelmintics (therapeutic use)
  • Benzimidazoles (therapeutic use)
  • Helminthiasis (drug therapy)
  • Humans
  • Intestinal Diseases, Parasitic (drug therapy)
  • Mebendazole (therapeutic use)
  • Praziquantel (therapeutic use)
  • Thailand
  • Treatment Outcome

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