Abstract |
The efficacy of a single dose of benzimidazole, drugs commonly used for the treatment of Ascaris and hookworm, was evaluated against one of the tiny-sized intestinal flukes, Haplorchis sp in the endemic area where mixed infections of roundworms and flatworms existed. At day 7 after treatment, albendazole (400 mg) induced 42.5% cure rate, mebendazole (500 mg) a cure rate of 32.4%, on the other hand, praziquantel (40 mg/kg) gave 94.6% cure rate and the placebo at 15.9%. At the single dose, benzimidazole could not completely expelled the haplorchid; but could reduce one third to two fifth of the infection, similar to the drugs efficacy against Trichuris infection.
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Authors | Jitra Waikagul, Dorn Watthanakulpanich, Chatree Muennoo, Wanna Maipanich, Surapol Sa-nguankiat, Somchit Phubampen |
Journal | Journal of the Medical Association of Thailand = Chotmaihet thangphaet
(J Med Assoc Thai)
Vol. 88
Issue 2
Pg. 233-7
(Feb 2005)
ISSN: 0125-2208 [Print] Thailand |
PMID | 15962676
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anthelmintics
- Benzimidazoles
- Praziquantel
- Mebendazole
- benzimidazole
- Albendazole
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Topics |
- Albendazole
(therapeutic use)
- Anthelmintics
(therapeutic use)
- Benzimidazoles
(therapeutic use)
- Helminthiasis
(drug therapy)
- Humans
- Intestinal Diseases, Parasitic
(drug therapy)
- Mebendazole
(therapeutic use)
- Praziquantel
(therapeutic use)
- Thailand
- Treatment Outcome
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