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[Therapeutic effect of L-ornithine-L-aspartate on liver cirrhosis complicated by hepatic encephalopathy].

AbstractOBJECTIVE: METHODS:
Eighty-five patient with liver cirrhosis complicated by hepatic encephalopathy were divided into therapy group (n=45) and control group (n=40). Patients in the control group were treated with routine comprehensive therapy, and those in the therapy group received additional intravenous administration with 40 ml L-ornithine-L-aspartate in 250 ml 10% glucose and saline (once daily, 7 days for a treatment course).
RESULTS:
L-ornithine-L-aspartase significantly decreased blood ammonia and improved hepatic function (P<0.05 or 0.01). The therapeutic effects of therapy group was better than that of the control group (P<0.05), and no significant side effect was observed in L-ornithine-L-aspartate treatment.
CONCLUSION:
L-ornithine-L-aspartate is effective for hepatic encephalopathy and has not obvious side effect.
AuthorsMing-fei Chen, Ru-cheng Li, Chang-hong Chen, Xiao-ci Gao
JournalDi 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA (Di Yi Jun Yi Da Xue Xue Bao) Vol. 25 Issue 6 Pg. 718-9, 722 (Jun 2005) ISSN: 1000-2588 [Print] China
PMID15958319 (Publication Type: English Abstract, Journal Article, Randomized Controlled Trial)
Chemical References
  • Dipeptides
  • ornithylaspartate
Topics
  • Dipeptides (therapeutic use)
  • Female
  • Hepatic Encephalopathy (drug therapy, etiology)
  • Humans
  • Infusions, Intravenous
  • Liver Cirrhosis (complications, drug therapy)
  • Male
  • Middle Aged

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