Abstract | BACKGROUND AND PURPOSE: MR examination of infants with kernicterus shows abnormal changes in signal intensity in various parts of the brain, including the globus pallidus and subthalamic regions. The purpose of this study was to retrospectively analyze proton ((1)H) MR spectroscopic data to see if the MR spectroscopic profiles of infants with hyperbilirubinemia and symptoms of kernicterus provide new insights into the pathophysiology of bilirubin neurotoxicity. METHODS: Six patients aged 3 days to 3 weeks, with hyperbilirubinemia and symptoms of kernicterus underwent MR imaging and MR spectroscopy with a single-voxel point-resolved spectroscopic sequence. The voxel of interest was centered in the basal ganglia with CSF excluded. Quantitative analysis was done by using LCModel. Between-subject comparisons were based on metabolite ratios relative to creatine. RESULTS: CONCLUSION:
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Authors | Wendy K Oakden, Aideen M Moore, Susan Blaser, Michael D Noseworthy |
Journal | AJNR. American journal of neuroradiology
(AJNR Am J Neuroradiol)
2005 Jun-Jul
Vol. 26
Issue 6
Pg. 1571-4
ISSN: 0195-6108 [Print] United States |
PMID | 15956531
(Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
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Topics |
- Female
- Humans
- Hydrogen
- Infant
- Infant, Newborn
- Kernicterus
(diagnosis, metabolism)
- Magnetic Resonance Spectroscopy
- Male
- Retrospective Studies
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