A new botulinum toxin type A free of complexing proteins for treatment of cervical dystonia.

Abstract

A new botulinum toxin type A free of complexing proteins (NT 201) was compared with BOTOX in patients with cervical dystonia by means of a double-blind noninferiority trial. Four hundred sixty-three patients received IM injections of 70 to 300 U of NT 201 or BOTOX and were followed up over 16 weeks. The study clearly shows that NT 201 is at least as effective and safe as BOTOX.

• Authors: R Benecke, W H Jost, P Kanovsky, E Ruzicka, G Comes, S Grafe
• Journal: Neurology (Neurology) Vol. 64 Issue 11 Pg. 1949-51 (Jun 14 2005) ISSN: 1526-632X [Electronic] United States
• PMID: 15955951 (Publication Type: Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies
• Botulinum Toxins, Type A
• incobotulinumtoxinA

Topics

• Antibodies (drug effects, immunology)
• Botulinum Toxins, Type A (administration & dosage, adverse effects, chemistry)
• Disability Evaluation
• Dose-Response Relationship, Drug
• Double-Blind Method
• Drug Resistance (immunology)
• Humans
• Muscle Contraction (drug effects, physiology)
• Neck Muscles (drug effects, physiopathology)
• Torticollis (drug therapy, physiopathology)
• Treatment Outcome