HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Outpatient misoprostol cervical ripening without subsequent induction of labor to prevent post-term pregnancy.

AbstractBACKGROUND:
Interventions that may help shorten the duration of pregnancy in an African setting where facilities for fetal monitoring in post-term pregnancy are limited, and induction is not without its hazards, are needed.
AIM:
To determine whether outpatient administration of intravaginal misoprostol safely decreases the interval to delivery in postdate pregnancies.
DESIGN:
Open randomized controlled trial.
SETTING:
Zonal district hospitals, Kwale, Southern Nigeria (August 2000 to October 2001).
METHODS:
Seventy-seven women were randomized at 40 weeks gestation to receive either 25 microg misoprostol intravaginally (38) or gentle cervical assessment only (39) on an outpatient basis. Subjects were then allowed to go into spontaneous labor unless an indication for induction developed.
MAIN OUTCOME MEASURES:
Interval to delivery, duration of labor, and incidence of side-effects.
RESULTS:
Misoprostol was associated with significant decrease in mean time to delivery (4.5 +/- 4.1 versus 7.4 +/- 5.2 days; P = 0.008), earlier gestational age at delivery (40.6 +/- 0.6 versus 41.4 +/- 0.05 weeks; P < 0.001) and shorter duration of active labor (6.1 +/- 4.0 versus 8.2 +/- 5.3 h; P = 0.028), without any significant increase in fetal distress, low Apgar score at delivery or other side-effects.
CONCLUSION:
Outpatient administration of low-dose misoprostol can safely shorten the length of gestation in postdate pregnancies.
AuthorsVictor O Oboro, Tabs O Tabowei
JournalActa obstetricia et gynecologica Scandinavica (Acta Obstet Gynecol Scand) Vol. 84 Issue 7 Pg. 628-31 (Jul 2005) ISSN: 0001-6349 [Print] United States
PMID15954870 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
Chemical References
  • Oxytocics
  • Misoprostol
Topics
  • Administration, Intravaginal
  • Adult
  • Ambulatory Care
  • Cervical Ripening (drug effects)
  • Chi-Square Distribution
  • Female
  • Gestational Age
  • Humans
  • Misoprostol (administration & dosage)
  • Oxytocics (administration & dosage)
  • Pregnancy
  • Pregnancy Outcome
  • Pregnancy, Prolonged (drug effects)
  • Statistics, Nonparametric

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: