Sertaconazole: updated review of a topical antifungal agent.

Abstract

Sertaconazole is an imidazole-type antifungal agent that has shown considerable in vitro activity against pathogenic fungi. Various studies carried out in animal models, clinical and toxicologic trials have confirmed the value of sertaconazole in the topical treatment of superficial mycoses in dermatology and gynecology. After several years of clinical experience in the topical treatment of dermatophytosis and Tinea versicolor, the substance has been approved for gynecologic candidiasis in Europe. Sertaconazole has a wide action spectrum that includes yeasts and dermatophyte fungi, and it is also active against bacteria, mainly Gram-positive cocci, making it highly efficient in the treatment of polymicrobial infections. The recent approval of the molecule by the US Food and Drug Administration, and the appearance of a new formulation of sertaconazole for the treatment of onychomycoses on a weekly administrative basis, are all data relevant to the process of marketing the product.

• Authors: Alfonso J Carrillo-Muñoz, Gustavo Giusiano, Pilar Ariadna Ezkurra, Guillermo Quindós
• Journal: Expert review of anti-infective therapy (Expert Rev Anti Infect Ther) Vol. 3 Issue 3 Pg. 333-42 (Jun 2005) ISSN: 1744-8336 [Electronic] England
• PMID: 15954850 (Publication Type: Journal Article, Review)

Chemical References

• Antifungal Agents
• Imidazoles
• Thiophenes
• sertaconazole

Topics

• Animals
• Antifungal Agents (chemistry, pharmacology, therapeutic use)
• Humans
• Imidazoles (chemistry, pharmacology, therapeutic use)
• Mycoses (drug therapy)
• Thiophenes (chemistry, pharmacology, therapeutic use)