Thymidylate synthase promoter tandem repeat and MTHFD1 R653Q polymorphisms modulate the risk for migraine conferred by the MTHFR T677 allele.

Abstract

There is growing evidence that folate metabolism is involved in migraine pathophysiology, mainly in migraine with aura. Even though folate metabolism is regulated by a number of enzymes, only two functional polymorphisms have been tested in association studies with migraine. Here, we have explored the possible role in migraine of other folate-metabolizing enzymes which are in close interdependency with 5',10'-methylenetetrahydrofolate reductase analyzing functional polymorphisms of these enzymes in a case-control study. Individually, thymidylate synthase (TS), methenyltetrahydrofolate cyclohydrolase formyltetrahydrofolate synthase (MTHFD1), or methionine synthase (MS) polymorphisms did not modify the general risk for suffering migraine. Nevertheless, we observed a strong interaction between TS and MTHFR mutated genotypes, which increased over 8-fold the risk for experiencing aura among migraineurs; MTHFD1 and MTHFR mutated genotypes also increased together the risk for migraine in general (OR = 3.08; 95% CI = 1.3-7.4). We conclude that the pathogenetic role of the MTHFR T677 allele in migraine is modulated by functional polymorphisms of TS and MTHFD1.

• Authors: Agustín Oterino, Natalia Valle, Julio Pascual, Yolanda Bravo, Pedro Muñoz, Jesús Castillo, Carlos Ruiz-Alegría, Pablo Sánchez-Velasco, Francisco Leyva-Cobián, Carmen Cid
• Journal: Brain research. Molecular brain research (Brain Res Mol Brain Res) Vol. 139 Issue 1 Pg. 163-8 (Sep 13 2005) ISSN: 0169-328X [Print] Netherlands
• PMID: 15953655 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Folic Acid
• Methylenetetrahydrofolate Reductase (NADPH2)
• Thymidylate Synthase
• Methenyltetrahydrofolate Cyclohydrolase
• Formate-Tetrahydrofolate Ligase

Topics

• Adult
• Case-Control Studies
• Female
• Folic Acid (metabolism)
• Formate-Tetrahydrofolate Ligase (genetics, metabolism)
• Genetic Predisposition to Disease
• Humans
• Methenyltetrahydrofolate Cyclohydrolase (genetics, metabolism)
• Methylenetetrahydrofolate Reductase (NADPH2) (genetics, metabolism)
• Middle Aged
• Migraine Disorders (genetics, physiopathology)
• Polymorphism, Genetic
• Promoter Regions, Genetic
• Risk Factors
• Tandem Repeat Sequences
• Thymidylate Synthase (genetics, metabolism)