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Linezolid-induced optic neuropathy.

AbstractPURPOSE:
To report a case of optic neuropathy associated with prolonged use of a new antibiotic, linezolid.
DESIGN:
Interventional case report.
METHODS:
Optic and peripheral neuropathy occurred in a 27-year-old woman who was undergoing prolonged linezolid therapy for osteomyelitis. The use of corticosteroid exacerbated visual loss. Discontinuation of the linezolid therapy resulted in marked improvement of optic neuropathy.
RESULTS:
Linezolid-induced optic neuropathy was diagnosed in this case, because prolonged linezolid therapy was performed at a higher dose than usual and because the patient recovered after linezolid therapy was discontinued.
CONCLUSIONS:
With prolonged linezolid therapy, ophthalmologists should be aware that bilateral optic neuropathy can occur and that corticosteroids are not indicated for this neuropathy.
AuthorsTomohiro Saijo, Keiko Hayashi, Hideyuki Yamada, Masato Wakakura
JournalAmerican journal of ophthalmology (Am J Ophthalmol) Vol. 139 Issue 6 Pg. 1114-6 (Jun 2005) ISSN: 0002-9394 [Print] United States
PMID15953450 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Acetamides
  • Anti-Infective Agents
  • Oxazolidinones
  • Linezolid
Topics
  • Acetamides (adverse effects)
  • Adult
  • Anti-Infective Agents (adverse effects)
  • Female
  • Humans
  • Linezolid
  • Optic Nerve Diseases (chemically induced)
  • Oxazolidinones (adverse effects)
  • Peripheral Nervous System Diseases (chemically induced)

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