Neonatal skin barrier: structure, function, and disorders.

Abstract

The development of the human skin from intrauterine to extrauterine life is a balletic interplay of maturing layers and interlocking structures. We discuss this transition and then branch out to touch on issues of premature infant as well as neonatal skin care. Disruption of the barrier function due to toxins and development errors are expounded upon. Staph scalded skin syndrome, collodion membrane, bullous congenital ichthyosiform erythroderma, autosomal recessive ichthyosis (lamellar and congenital ichthyosiform erythroderma), and harlequin fetus are used as examples of these disruptions. Discussion of therapy with the authors' experience highlights each disease.

• Authors: Tor Shwayder, Tom Akland
• Journal: Dermatologic therapy (Dermatol Ther) 2005 Mar-Apr Vol. 18 Issue 2 Pg. 87-103 ISSN: 1396-0296 [Print] United States
• PMID: 15953139 (Publication Type: Journal Article, Review)

Topics

• Humans
• Infant, Newborn
• Skin Diseases (congenital, physiopathology)
• Skin Physiological Phenomena