Abstract |
In order to assess whether light exposure at night influences the growth of mammary tumors, as well as the role of melatonin in this process, female rats bearing DMBA-induced mammary adenocarcinomas were exposed to different lighting environments. Animals exposed to light-at-night, especially those under a constant dim light during the darkness phase, showed: (a) significantly higher rates of tumor growth as well as lower survival than controls, (b) higher concentration of serum estradiol, and (c) lower nocturnal excretion of 6-sulfatoxymelatonin, without there being differences between nocturnal and diurnal levels. These results suggest that circadian and endocrine disruption induced by light pollution, could induce the growth of mammary tumors.
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Authors | Samuel Cos, Dolores Mediavilla, Carlos Martínez-Campa, Alicia González, Carolina Alonso-González, Emilio J Sánchez-Barceló |
Journal | Cancer letters
(Cancer Lett)
Vol. 235
Issue 2
Pg. 266-71
(Apr 28 2006)
ISSN: 0304-3835 [Print] Ireland |
PMID | 15950374
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- 6-sulfatoxymelatonin
- Estradiol
- 9,10-Dimethyl-1,2-benzanthracene
- Melatonin
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Topics |
- 9,10-Dimethyl-1,2-benzanthracene
- Adenocarcinoma
(chemically induced, pathology)
- Animals
- Body Weight
- Circadian Rhythm
- Darkness
- Estradiol
(blood)
- Estrus
- Female
- Light
- Mammary Neoplasms, Experimental
(chemically induced, mortality, pathology)
- Melatonin
(analogs & derivatives, urine)
- Rats
- Rats, Sprague-Dawley
- Survival Rate
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