Abstract | PURPOSE: Recent studies show the interesting efficacy of different drug combinations for the spontaneous expulsion of distal ureteral stones. We performed a randomized, prospective study to assess and compare the efficacy of 3 drugs as medical expulsive therapy for distal ureteral calculi. MATERIALS AND METHODS: RESULTS: The expulsion rate was significantly higher in group 2 (97.1%) than in groups 1 (64.3%, p <0.0001) or 3 (77.1%, p <0.0001). Group 2 significantly achieved stone passage in a shorter time than the other 2 groups and showed a significantly decreased number of hospitalizations as well as a better decrease in endoscopic procedures performed to remove the stone. The control of renal colic pain was significantly superior in group 2 compared with the other groups, resulting in fewer workdays lost. Group 3 showed lower analgesic use and decreased workdays lost compared with group 1. No difference in side effects was observed among the groups. CONCLUSIONS: Medical expulsive therapy should be considered for distal ureterolithiasis without complications before ureteroscopy or extracorporeal lithotripsy. The use of tamsulosin in this treatment regimen produced stone expulsion in almost all cases in a short time, allowing complete home patient treatment.
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Authors | Marco Dellabella, Giulio Milanese, Giovanni Muzzonigro |
Journal | The Journal of urology
(J Urol)
Vol. 174
Issue 1
Pg. 167-72
(Jul 2005)
ISSN: 0022-5347 [Print] United States |
PMID | 15947613
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Adrenergic alpha-Antagonists
- Calcium Channel Blockers
- Parasympatholytics
- Sulfonamides
- Phloroglucinol
- Tamsulosin
- Nifedipine
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Topics |
- Adrenergic alpha-Antagonists
(therapeutic use)
- Adult
- Calcium Channel Blockers
(therapeutic use)
- Female
- Humans
- Male
- Nifedipine
(therapeutic use)
- Parasympatholytics
(therapeutic use)
- Phloroglucinol
(therapeutic use)
- Prospective Studies
- Sulfonamides
(therapeutic use)
- Tamsulosin
- Ureteral Calculi
(drug therapy)
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