Abstract | BACKGROUND & OBJECTIVE: METHODS: Expression of CK19 mRNA in bone marrows of 65 breast cancer patients, 15 benign breast disease patients, and 8 healthy volunteers was detected by reverse transcription-polymerase chain reaction (RT-PCR). Correlation of CK19 mRNA expression to clinicopathologic features of the 65 breast cancer patients was analyzed. RESULTS: Positive rate of CK19 mRNA was 33.8% in the 65 breast cancer patients, and 0 in both benign breast disease patients and healthy volunteers. Expression of CK19 mRNA was positively correlated with tumor size and clinical stage (P < 0.05), but was not related to age and lymph node status (P > 0.05). In addition, positive rate of CK19 mRNA was positively correlated with carcinoembryonic antigen (CEA) in peripheral blood (r=0.372, P=0.002). CONCLUSIONS:
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Authors | Bao-Jiang Li, Xiao-Ping Huang, Wei-Dong Wei, Jun-Ye Wang, Xiao-Dong Su, Xu Zhang, Wen-Shan Hong, Jun Tang, Lan-Jun Zhang, Hao Long, Ming-Tian Yang, Tie-Hua Rong |
Journal | Ai zheng = Aizheng = Chinese journal of cancer
(Ai Zheng)
Vol. 24
Issue 6
Pg. 735-9
(Jun 2005)
China |
PMID | 15946491
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Carcinoembryonic Antigen
- Keratin-19
- RNA, Messenger
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Topics |
- Adult
- Aged
- Bone Marrow
(metabolism)
- Breast Neoplasms
(metabolism, pathology)
- Breast Neoplasms, Male
(metabolism, pathology)
- Carcinoembryonic Antigen
(blood)
- Carcinoma, Ductal, Breast
(metabolism, pathology)
- Female
- Fibroadenoma
(blood, metabolism, pathology)
- Humans
- Keratin-19
(biosynthesis, genetics)
- Lymphatic Metastasis
- Male
- Middle Aged
- Neoplasm Staging
- RNA, Messenger
(biosynthesis, genetics)
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