Myocardial perfusion SPECT imaging in patients with myocardial bridging.

Abstract

BACKGROUND:

Although myocardial perfusion single photon emission computed tomography (SPECT) imaging is widely used to assess myocardial ischemia in patients with known or suspected coronary artery disease, only a few patients with myocardial bridging have been evaluated with nuclear techniques. Furthermore, it has been suggested that dipyridamole stress images might underestimate perfusion defects compared with exercise stress images. This study was done to determine the concordance of exercise stress SPECT images with that obtained by dipyridamole stress SPECT images as a means of detecting ischemia in patients with myocardial bridging.

METHODS AND RESULTS:

Sixteen consecutive patients with angina and normal arteries but myocardial bridging of the left anterior descending artery underwent rest-exercise stress SPECT imaging. Within 2 weeks after angiograms were obtained, only dipyridamole stress images were repeated. The mean angiographic systolic occlusion within the myocardial bridges was 73% +/- 10%. Overall, the prevalence of an abnormal scan was no different in patients who underwent exercise stress myocardial perfusion imaging (MPI) as compared with patients who underwent dipyridamole stress MPI (14/16 [88%] vs 13/16 [81%], respectively; P = .953). Exercise stress MPI showed a higher stress score than dipyridamole stress MPI, but the difference did not reach statistical significance (7.5 +/- 3.3 vs 6 +/- 2.7, P = .147). The strength of agreement among exercise stress MPI and dipyridamole stress MPI studies was good (kappa = 0.765; 95% CI, 0.318 to 1.211; P < .05).

CONCLUSIONS:

Cardiac SPECT studies can be used effectively for assessing ischemia in patients with angina and myocardial bridging. The evaluation of myocardial perfusion with dipyridamole stress SPECT imaging showed a good agreement with exercise stress SPECT imaging for the detection of ischemia in this group of patients.

• Authors: Enrique Vallejo, Mario Morales, Isabel Sánchez, Gustavo Sánchez, José Carlos Alburez, David Bialostozky
• Journal: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology (J Nucl Cardiol) 2005 May-Jun Vol. 12 Issue 3 Pg. 318-23 ISSN: 1071-3581 [Print] United States
• PMID: 15944537 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)

Chemical References

• Radiopharmaceuticals
• Vasodilator Agents
• Dipyridamole
• Technetium Tc 99m Sestamibi

Topics

• Coronary Vessel Anomalies (complications, diagnostic imaging)
• Coronary Vessels (diagnostic imaging)
• Dipyridamole
• Exercise Test (methods)
• Female
• Humans
• Image Enhancement (methods)
• Male
• Myocardial Ischemia (diagnostic imaging, etiology, prevention & control)
• Radiopharmaceuticals
• Reproducibility of Results
• Risk Assessment (methods)
• Sensitivity and Specificity
• Severity of Illness Index
• Technetium Tc 99m Sestamibi
• Tomography, Emission-Computed, Single-Photon (methods)
• Vasodilator Agents