Effect of galnon on induction of long-term potentiation in dentate gyrus of C57BL/6 mice.

Abstract

The impairment of cognitive performance by galanin administration in rodents indicates a possible modulating effect of this neuropeptide on long-term potentiation (LTP) induction in the hippocampal formation. Galnon is a non-peptide, systemically active galanin receptor agonist which has been tested in feeding, seizure and forced swim task in in vivo rodent experimental models. Similarly to galanin (1-29) (i.c.v.), galnon (i.p.) has exhibited anticonvulsant effects in rats. We have investigated the effect of galnon on the synaptic transmission and plasticity in hippocampal dentate gyrus (DG) of C57Bl/6 mice and compared the galnon effects to the effect of galanin (1-29) and galmic, a non-peptide galanin receptor agonist. Similarly to galanin (1-29) and galmic, superfusion of galnon did not alter the input-output responses in DG. Administration of galnon (1 microM) significantly attenuated the LTP induction by 85.5 +/- 1% by 51 min after high frequency trains stimulation. This result was very similar to the effect of galanin (1-29) and galmic, which caused an 80 +/- 1.5% and 94 +/- 2% reduction in the level of field potentiation, respectively. The PPF responses, however, were not altered due to galnon superfusion which is in contrast to the effect of galanin (1-29) or galmic. In summary, these data indicate that the systemically active, non-peptide galanin receptor agonist, galnon can exert similar effects to galanin (1-29) in attenuation of DG LTP in mice.

• Authors: H Badie-Mahdavi, M M Behrens, J Rebek, T Bartfai
• Journal: Neuropeptides (Neuropeptides) Vol. 39 Issue 3 Pg. 249-51 (Jun 2005) ISSN: 0143-4179 [Print] Netherlands
• PMID: 15944018 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• 7-((9-fluorenylmethoxycarbonyl)cyclohexylalanyllysyl)amino-4-methylcoumarin
• Coumarins
• Peptides, Cyclic
• galmic
• Galanin

Topics

• Animals
• Coumarins (pharmacology)
• Dentate Gyrus (drug effects, physiology)
• Galanin (pharmacology)
• Long-Term Potentiation (drug effects)
• Mice
• Mice, Inbred C57BL
• Neuronal Plasticity (drug effects)
• Peptides, Cyclic (pharmacology)