[Study on the dynamics of IgG antibody in 311 patients with severe acute respiratory syndrome].

Abstract

OBJECTIVE:

To detect the level and dynamic change of severe acute respiratory syndrome (SARS)-coronavirus-specific IgG antibody in conavalescent SARS patients, and to provide information for prevention and vaccine development.

METHODS:

IgG antibody against coronavirus was detected by ELISA in the blood of 311 convalescent SARS patients for every 2 - 4 weeks. Stata 7.0 statistics software was used to analyse the results.

RESULTS:

IgG antibody was detected positive on each testing of all the convalescent patients and its peak appeared 35 days after recovery. IgG antibody level showed a 35.8% decrease within one year.

CONCLUSION:

Data showed that all the SARS convalescent patients had generated high level of specific IgG antibody against coronavirus in the early stage of recovery, but the antibody level declined along with the progress of convalescence, suggesting that the detection of the IgG antibody should go on until it disappeared.

• Authors: Bao-xing Fan, Li-xin Xie, Liang-an Chen, Wei-jun Chen, Jie Wen, You-ning Liu
• Journal: Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi (Zhonghua Liu Xing Bing Xue Za Zhi) Vol. 26 Issue 3 Pg. 194-6 (Mar 2005) ISSN: 0254-6450 [Print] China
• PMID: 15941507 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Viral
• Immunoglobulin G

Topics

• Adolescent
• Adult
• Aged
• Antibodies, Viral (blood)
• Convalescence
• Enzyme-Linked Immunosorbent Assay
• Female
• Humans
• Immunoglobulin G (blood)
• Male
• Middle Aged
• Severe acute respiratory syndrome-related coronavirus (immunology)
• Severe Acute Respiratory Syndrome (immunology)