| Abstract | Anhedonia, a core symptom of depression, correlates with motor alterations in major depressive disorder and has been assumed to be frequent in depressed patients with Parkinson's disease (PD). In the present study, the authors assessed for the first time frequency of anhedonia in patients with idiopathic Parkinson's disease (N = 657) and the relationship of anhedonia and parkinsonian motor deficits during treatment with pramipexole. Mild depression was present in 47% of the patients and moderate to severe depression in 22%. Anhedonic individuals included 45.7% of all patients and 79.7% of depressed Parkinson's disease patients. Anhedonic Parkinson's disease patients had greater motor deficits, restrictions in activities of daily living, and depression compared to nonanhedonic patients. Frequency of anhedonia and depression was significantly reduced during treatment with pramipexole. Future studies should further investigate antianhedonic efficacy of dopamine agonists including pramipexole in depressed patients with Parkinson's disease. |
| Authors | Matthias R Lemke, H Michael Brecht, Juergen Koester, Peter H Kraus, Heinz Reichmann
(Affiliation: Center of Psychiatry and Neurology, Rhine Clinic Bonn, Germany. mr.lemke at lvr.de)
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| Journal | The Journal of neuropsychiatry and clinical neurosciences
(J Neuropsychiatry Clin Neurosci)
Vol. 17
Issue 2
Pg. 214-20
( 2005)
ISSN: 0895-0172 United States |
| PMID | 15939976
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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| Chemical References |
- Antiparkinson Agents
- Benzothiazoles
- Thiazoles
- pramipexol
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| Topics |
- Activities of Daily Living
- Aged
- Aging
(psychology)
- Antiparkinson Agents
(administration & dosage, therapeutic use)
- Benzothiazoles
- Depression
(etiology, psychology)
- Dose-Response Relationship, Drug
- Female
- Humans
- Male
- Parkinson Disease
(complications, drug therapy, psychology)
- Prospective Studies
- Psychiatric Status Rating Scales
- Psychomotor Performance
(drug effects, physiology)
- Thiazoles
(administration & dosage, therapeutic use)
|
