Abstract | OBJECTIVE: Reperfusion treatment modalities used in the routine treatment protocols of acute myocardial infarction (AMI) were found to be ineffective in establishing the nutritional cellular reperfusion in the microvascular environment even they succeed to open the infarct related artery. Glucose- insulin- potassium ( GIK) solution, which is presumed to stimulate the glycolytic pathway, is experimentally proven to be the most efficacious substrate for the preservation of energy production and therefore the myocardial viability, in the setting of acute ischemia. METHODS: We compared, 54 patients who suffered AMI and received GIK solution (300 g glucose+50 IU crystallized insulin+80 mEq potassium chloride in one liter solution) in addition to conventional treatment (GIK group) with 27 patients who were traditionally treated (control group) for in-hospital and early-term (1 month) cardiac morbidity. We also compared the two groups in terms of heart rate variability (HRV). RESULTS: Eight patients in the control group developed new-onset symptomatic congestive heart failure whereas only 5 patients in GIK group were found to have such a cardiac morbidity (p=0.01). Reduced HRV (<50 ms) was found in 3 patients of control group whereas no patient in GIK group had abnormal HRV (p=0.01). CONCLUSION:
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Authors | Baybars Türel, Kani Gemici, Ibrahim Baran, Dilek Yeşilbursa, Sümeyye Güllülü, Ali Aydinlar, Akin Serdar, Ali Riza Kazazoğlu, Ethem Kumbay, Jale Cordan |
Journal | Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology
(Anadolu Kardiyol Derg)
Vol. 5
Issue 2
Pg. 90-4
(Jun 2005)
ISSN: 1302-8723 [Print] Turkey |
PMID | 15939681
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Cardioplegic Solutions
- Insulin
- glucose-insulin-potassium cardioplegic solution
- Glucose
- Potassium
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Topics |
- Angioplasty, Balloon, Coronary
(methods)
- Cardioplegic Solutions
(administration & dosage)
- Female
- Glucose
(administration & dosage)
- Heart Rate
(drug effects)
- Humans
- Insulin
(administration & dosage)
- Male
- Middle Aged
- Myocardial Infarction
(therapy)
- Myocardial Reperfusion Injury
(prevention & control)
- Potassium
(administration & dosage)
- Treatment Outcome
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