Abstract | BACKGROUND: METHODS: We retrospectively reviewed the clinical characteristics and computed tomography (CT) findings for 16 patients with cancer and PZ and for 29 contemporaneous patients with cancer and IPA at the time of infection onset (2002-2004). Patients with mixed infections were excluded. Parameters predictive of PZ by univariate analysis were included in a logistic regression model. RESULTS: Almost all patients with PZ (15 of 16) and IPA (28 of 29) had underlying hematological malignancies and typical risk factors for invasive mold infections. In logistic regression analysis of clinical characteristics, concomitant sinusitis (odds ratio [OR], 25.7; 95% confidence interval [CI], 1.47-448.15; P = .026) and voriconazole prophylaxis (OR, 7.76; 95% CI, 1.32-45.53; P = .023) were significantly associated with PZ. The presence of multiple (> or = 10) nodules (OR, 19.8; 95% CI, 1.94-202.29; P = .012) and pleural effusion (OR, 5.07; 95% CI, 1.06-24.23; P = .042) at the time that the patient underwent the initial CT were both independent predictors of PZ in the logistic regression analysis of radiological parameters. No difference occurred in the frequency of other CT findings suggestive of pulmonary mold infections (e.g., masses, cavities, halo sign, or air-crescent sign) between the 2 patient groups. CONCLUSIONS: PZ in immunocompromised patients with cancer could potentially be distinguished from IPA on the basis of clinical and radiological parameters; prospective validation is needed.
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Authors | Georgios Chamilos, Edith M Marom, Russell E Lewis, Michail S Lionakis, Dimitrios P Kontoyiannis |
Journal | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
(Clin Infect Dis)
Vol. 41
Issue 1
Pg. 60-6
(Jul 01 2005)
ISSN: 1537-6591 [Electronic] United States |
PMID | 15937764
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Adult
- Aged
- Aspergillosis
(diagnostic imaging, epidemiology, microbiology, physiopathology)
- Aspergillus
(classification, isolation & purification)
- Female
- Humans
- Lung Diseases, Fungal
(diagnostic imaging, epidemiology, microbiology, physiopathology)
- Male
- Middle Aged
- Mucor
(classification, isolation & purification)
- Mucormycosis
(diagnostic imaging, epidemiology, microbiology)
- Neoplasms
(complications)
- Predictive Value of Tests
- Retrospective Studies
- Rhizopus
(classification, isolation & purification)
- Tomography, X-Ray Computed
- Zygomycosis
(diagnostic imaging, epidemiology, microbiology, physiopathology)
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