HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Importance of coronary artery spasm in alcohol-related unexplained syncope.

Abstract
To examine the role of coronary artery spasm in patients with syncope after alcohol ingestion, we performed an intracoronary ergonovine provocation test in 7 male patients (39 to 73 years old, mean 54 years) with alcohol-related syncope which remained unexplained despite noninvasive cardiovascular and neurological examinations. No patients had structural heart disease or significant coronary artery stenosis. Ergonovine was continuously infused into each coronary artery at a rate of 10 micrograms/min for up to 5 min. Coronary artery spasm with ST-segment elevation was induced in 4 of 7 patients. Chest pain before syncope or history of chest pain were not present in 3 of 4 patients with a positive ergonovine test. Multivessel coronary artery spasm was induced in 3 patients. One patient presented with triple vessel coronary artery spasm progressing to near syncope as a result of profound hypotension and ventricular tachycardia during provocation. Coronary artery spasm was promptly relieved by intracoronary isosorbide dinitrate infusion. All patients with a positive ergonovine test were treated with calcium antagonist and did not experience syncope during follow-up. These results suggest that coronary artery spasm is one of the important causes of syncope after alcohol ingestion.
AuthorsY Tanabe, M Yamazoe, Y Igarashi, Y Tamura, K Tsuchida, K Otsuka, H Uchiyama, T Shu, A Shibata
JournalJapanese heart journal (Jpn Heart J) Vol. 33 Issue 2 Pg. 135-44 (Mar 1992) ISSN: 0021-4868 [Print] JAPAN
PMID1593745 (Publication Type: Journal Article)
Chemical References
  • Ergonovine
Topics
  • Adult
  • Aged
  • Alcoholic Beverages (adverse effects)
  • Coronary Angiography
  • Coronary Vasospasm (chemically induced, physiopathology, radiography)
  • Electrocardiography
  • Ergonovine
  • Humans
  • Male
  • Middle Aged
  • Syncope (etiology, physiopathology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: