Effects of the potential 5-HT7 receptor agonist AS 19 in an autoshaping learning task.

Abstract

This work aimed to evaluate further the role of 5-HT7 receptors during memory formation in an autoshaping Pavlovian/instrumental learning task. Post-training administration of the potential 5-HT7 receptor agonist AS 19 or antagonist SB-269970 enhanced memory formation or had no effect, respectively. The AS 19 facilitatory effect was reversed by SB-269970, but not by the selective 5-HT1A antagonist WAY100635. Amnesia induced by scopolamine (cholinergic antagonist) or dizocilpine (NMDA antagonist) was also reversed by AS 19. Certainly, reservations regarding the selectivity of AS 19 for 5-HT7 and other 5-HT receptors in vivo are noteworthy and, therefore, its validity for use in animal models as a pharmacological tool. Having mentioned that, it should be noticed that together these data are providing further support to the notion of the 5-HT7 receptors role in memory formation. Importantly, this 5-HT7 receptor agonist AS 19 appears to represent a step forward respect to the notion that potent and selective 5-HT7 receptor agonists can be useful in the treatment of dysfunctional memory in aged-related decline and Alzheimer's disease.

• Authors: Georgina S Perez-García, A Meneses
• Journal: Behavioural brain research (Behav Brain Res) Vol. 163 Issue 1 Pg. 136-40 (Aug 30 2005) ISSN: 0166-4328 [Print] Netherlands
• PMID: 15936093 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• AS 19 compound
• Phenols
• Piperazines
• Pyrazoles
• Pyridines
• Receptors, Serotonin
• SB 269970
• Serotonin Receptor Agonists
• Sulfonamides
• Tetrahydronaphthalenes
• serotonin 7 receptor
• N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide

Topics

• Animals
• Association Learning (drug effects)
• Conditioning, Classical (drug effects)
• Male
• Memory (drug effects)
• Phenols (pharmacology)
• Piperazines (pharmacology)
• Pyrazoles (pharmacology)
• Pyridines (pharmacology)
• Rats
• Rats, Wistar
• Receptors, Serotonin (drug effects)
• Serotonin Receptor Agonists (pharmacology)
• Sulfonamides (pharmacology)
• Tetrahydronaphthalenes (pharmacology)