[Effects of acetylsalicylic acid and diquertin on platelet aggregation and hemorheological parameters in rats with cerebral ischemia].

Abstract

Rats with model cerebral ischemia were treated over 5 days with acetylsalicylic acid (in a single daily dose of 50 mg/kg via a gastric tube). This treatment decreased the level of platelet aggregation, while producing no statistically significant effect upon hemorheogical indices. The combined treatment with a complex of acetylsalicylic acid and diquertin (50 and 10 mg/kg via a gastric tube, respectively) also produced the antiaggregant effect, but additionally reduced the blood viscosity, erythrocyte aggregation, and fibrinogen content in the blood plasma.

• Authors: M B Plotnikova, a V Iamkin, O I Aliev, N A Tiukavkina
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 2005 Mar-Apr Vol. 68 Issue 2 Pg. 33-5 ISSN: 0869-2092 [Print] Russia (Federation)
• PMID: 15934364 (Publication Type: English Abstract, Journal Article)

Chemical References

• Drug Combinations
• Platelet Aggregation Inhibitors
• diquertin
• Fibrin
• Quercetin
• Aspirin

Topics

• Animals
• Aspirin (administration & dosage)
• Blood Viscosity (drug effects)
• Brain Ischemia (blood, drug therapy)
• Drug Combinations
• Erythrocyte Aggregation (drug effects)
• Fibrin (analysis)
• Male
• Platelet Aggregation (drug effects)
• Platelet Aggregation Inhibitors (administration & dosage)
• Quercetin (administration & dosage, analogs & derivatives)
• Rats
• Rats, Wistar