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Short-term dexamethasone treatment for symptomatic slit ventricle syndrome.

AbstractOBJECTIVE:
The objective was to report our positive experience of using dexamethasone to treat 13 patients with symptomatic slit ventricle syndrome (SVS).
METHODS:
Thirteen SVS patients who received dexamethasone during acute episodes were studied. The etiology for hydrocephalus was prematurity and intraventricular hemorrhage in 9 patients and neonatal meningitis, chorioamnionitis, Dandy-Walker variant, and congenital in 1 case each. The shunt was inserted at 1.8+/-1.0 months of age and SVS was diagnosed at 4.9+/-3.2 years of age.
RESULTS:
All patients reported relief and shorter duration of symptoms with dexamethasone. Surgical intervention was decided upon and carried out within 11+/-8 months of SVS diagnosis in 9 out of 13 patients. The other 4 are being monitored and continue to receive dexamethasone when needed.
CONCLUSIONS:
Dexamethasone appears to be a useful treatment in acutely increased intracranial pressure caused by SVS. It can provide temporary relief during the decision-making process of whether and when to perform surgery.
AuthorsAviva Fattal-Valevski, Liana Beni-Adani, Shlomi Constantini
JournalChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery (Childs Nerv Syst) Vol. 21 Issue 11 Pg. 981-4 (Nov 2005) ISSN: 0256-7040 [Print] Germany
PMID15933887 (Publication Type: Journal Article)
Chemical References
  • Dexamethasone
Topics
  • Acute Disease
  • Cerebral Ventricles (pathology)
  • Child
  • Child, Preschool
  • Dexamethasone (administration & dosage)
  • Drug Administration Schedule
  • Female
  • Follow-Up Studies
  • Humans
  • Hydrocephalus (drug therapy, etiology)
  • Infant
  • Infant, Newborn
  • Infant, Premature, Diseases (drug therapy, etiology)
  • Male
  • Syndrome
  • Ventriculoperitoneal Shunt

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