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Patellamide E: a new cyclic peptide from the ascidian Lissoclinum patella.

Abstract
A new cyclic peptide, patellamide E [1], was isolated from the ascidian Lissoclinum patella collected at Pulau Salu, Singapore. Its structure was determined by nmr spectroscopy, and its absolute configuration by acid hydrolysis and analysis of the derivatized constituent amino acids by hplc. Patellamide E was mildly cytotoxic against human colon tumor cells in vitro.
AuthorsL A McDonald, C M Ireland
JournalJournal of natural products (J Nat Prod) Vol. 55 Issue 3 Pg. 376-9 (Mar 1992) ISSN: 0163-3864 [Print] United States
PMID1593285 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Antineoplastic Agents
  • Peptides, Cyclic
  • patellamide E
  • Ozone
Topics
  • Animals
  • Antineoplastic Agents (isolation & purification, pharmacology)
  • Chemical Phenomena
  • Chemistry, Physical
  • Chromatography, High Pressure Liquid
  • Colonic Neoplasms (pathology)
  • Humans
  • Magnetic Resonance Spectroscopy
  • Molecular Conformation
  • Ozone
  • Peptides, Cyclic (isolation & purification, pharmacology)
  • Stereoisomerism
  • Tumor Cells, Cultured (drug effects)
  • Urochordata (chemistry)

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