Abstract |
A new cyclic peptide, patellamide E [1], was isolated from the ascidian Lissoclinum patella collected at Pulau Salu, Singapore. Its structure was determined by nmr spectroscopy, and its absolute configuration by acid hydrolysis and analysis of the derivatized constituent amino acids by hplc. Patellamide E was mildly cytotoxic against human colon tumor cells in vitro.
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Authors | L A McDonald, C M Ireland |
Journal | Journal of natural products
(J Nat Prod)
Vol. 55
Issue 3
Pg. 376-9
(Mar 1992)
ISSN: 0163-3864 [Print] United States |
PMID | 1593285
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Antineoplastic Agents
- Peptides, Cyclic
- patellamide E
- Ozone
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Topics |
- Animals
- Antineoplastic Agents
(isolation & purification, pharmacology)
- Chemical Phenomena
- Chemistry, Physical
- Chromatography, High Pressure Liquid
- Colonic Neoplasms
(pathology)
- Humans
- Magnetic Resonance Spectroscopy
- Molecular Conformation
- Ozone
- Peptides, Cyclic
(isolation & purification, pharmacology)
- Stereoisomerism
- Tumor Cells, Cultured
(drug effects)
- Urochordata
(chemistry)
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