Two related cinnamic Acid derivatives from Brazilian honey bee propolis, baccharin and drupanin, induce growth inhibition in allografted sarcoma S-180 in mice.

Abstract

Honey bee propolis is rich in cinnamic acid derivatives. Baccharin and drupanin from Brazilian honey bee propolis are cinnamic acid derivatives that contain prenyl moieties. We previously isolated these two compounds and demonstrated that they induce an apoptotic event in several tumor cell lines. In this study, we examined the tumoricidal activity of baccharin and drupanin in mice allografted with sarcoma S-180 and also studied the genotoxic effects on normal splenocytes using the alkaline single cell gel (comet) assay. We found that both baccharin and drupanin effectively suppressed growth of the tumor. Furthermore, these compounds induced a significant genotoxic effect on the tumor cells in comparison with normal splenocytes. Thus, baccharin and drupanin are potent tumor suppressive components of honeybee propolis.

• Authors: Satoshi Mishima, Yosuke Ono, Yoko Araki, Yukihiro Akao, Yoshinori Nozawa
• Journal: Biological & pharmaceutical bulletin (Biol Pharm Bull) Vol. 28 Issue 6 Pg. 1025-30 (Jun 2005) ISSN: 0918-6158 [Print] Japan
• PMID: 15930739 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cinnamates
• Growth Inhibitors
• Trichothecenes
• cinnamic acid
• Propolis
• baccharin

Topics

• Animals
• Bees
• Brazil
• Cinnamates (isolation & purification, pharmacology, therapeutic use)
• Dose-Response Relationship, Drug
• Drug Screening Assays, Antitumor (methods)
• Growth Inhibitors (isolation & purification, pharmacology, therapeutic use)
• Male
• Mice
• Propolis (isolation & purification, pharmacology, therapeutic use)
• Sarcoma 180 (drug therapy, pathology)
• Transplantation, Homologous
• Trichothecenes (isolation & purification, pharmacology, therapeutic use)