Childhood neutrophilic eccrine hidradenitis: a clinicopathologic and immunohistochemical study of 10 patients.

Abstract

BACKGROUND:

Neutrophilic eccrine hidradenitis (NEH) is occasionally reported in patients who have not received chemotherapy.

OBJECTIVE:

The purpose of this study was to describe the clinicopathologic features of NEH occurring in healthy children and to investigate the interleukin (IL)-8 expression in the cutaneous lesions.

METHODS:

Ten children with characteristic histologic features of NEH were collected from the Chang Gung Memorial Hospital. Their formalin-fixed, paraffin-embedded specimens were examined by immunohistochemical staining for IL-8.

RESULTS:

The age of first presentation at our clinic ranged from 6 months to 14 months with a median age of 9.1 months. The onset of the disease clustered in the summertime. The most common clinical appearance was multiple erythematous papules and nodules on the limbs. Two of 7 biopsy specimens grew coagulase-negative Staphylococcus . None of patients had underlying systemic disease and all had complete resolution of the lesions within 3 weeks. Immunohistochemical staining for IL-8 was negative in the 10 cases studied.

CONCLUSION:

Childhood NEH appears as urticaria-like erythematous nodules and plaques on the limbs, trunk, or scalp. This benign and limited disease occurs with a predilection for summer months. In our study, onset was in children less than 15 months of age. IL-8 was not detected in the cutaneous lesions.

• Authors: I-Hsin Shih, Yu-Huei Huang, Chih-Hsun Yang, Li-Cheng Yang, Hong-Shang Hong
• Journal: Journal of the American Academy of Dermatology (J Am Acad Dermatol) Vol. 52 Issue 6 Pg. 963-6 (Jun 2005) ISSN: 1097-6787 [Electronic] United States
• PMID: 15928612 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Interleukin-8

Topics

• Female
• Hidradenitis (metabolism, pathology)
• Humans
• Immunohistochemistry
• Infant
• Interleukin-8 (analysis, biosynthesis)
• Male