Abstract | BACKGROUND: METHODS: The infrarenal abdominal aorta was clamped in eighteen rabbits. Saline (group A), 20 mg/kg of ACPC (group B), or 10 mg/kg of ACPC (group C), was injected into the clamped aorta. The animals were neurologically evaluated by Tarlov's score. The spinal cord was obtained for histopathologic examination, including hematoxylin and eosin staining and terminal deoxynucleotidyl transferase-mediated dUTP- biotin nick end-labeling (TUNEL) staining method. RESULTS: Postoperative complete paraplegia with marked neuronal necrosis appeared in group A animals. Four of the six group C animals showed intact neurological function. Scattered TUNEL positive neurons were seen within areas containing necrotic cells in sections from paraplegic animals in group A. CONCLUSIONS:
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Authors | H Unno, T Jikuya, T Yamamoto, Y Sakakibara |
Journal | The Thoracic and cardiovascular surgeon
(Thorac Cardiovasc Surg)
Vol. 53
Issue 3
Pg. 133-7
(Jun 2005)
ISSN: 0171-6425 [Print] Germany |
PMID | 15926090
(Publication Type: Journal Article)
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Chemical References |
- Amino Acids, Cyclic
- Neuroprotective Agents
- Receptors, N-Methyl-D-Aspartate
- 1-aminocyclopropane-1-carboxylic acid
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Topics |
- Amino Acids, Cyclic
(administration & dosage, pharmacology, therapeutic use)
- Animals
- Disease Models, Animal
- In Situ Nick-End Labeling
- Neuroprotective Agents
(therapeutic use)
- Paraplegia
(prevention & control)
- Rabbits
- Receptors, N-Methyl-D-Aspartate
(agonists)
- Spinal Cord Injuries
(prevention & control)
- Spinal Cord Ischemia
(drug therapy, pathology)
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