Immunohistochemical study of epidermal growth factor and transforming growth factor-beta in the penetrating type of early gastric cancer.

Abstract

We report that the penetrating type of early gastric cancer (PEN) is a specific type of early gastric cancer and that the poorly differentiated PEN type could be considered an initial lesion of linitis plastica-type cancer. We performed an immunohistochemical study to clarify the role of growth factors (epidermal growth factor [EGF] and transforming growth factor-beta [TGF-beta]) in the PEN type of early gastric cancer. The results indicated that the PEN type of early gastric cancer has a high growth capacity. Moreover, it was suggested that EGF was involved in its specific infiltrative growth and that both EGF and TGF-beta were involved in its specific scirrhous growth. From these findings, it was assumed that the immunohistochemical staining of EGF and TGF-beta in endoscopic biopsy specimens was useful for the diagnosis of the PEN type of gastric cancer and also for the diagnosis of the initial lesion of linitis plastica-type gastric cancer.

• Authors: D Hirayama, T Fujimori, K Satonaka, T Nakamura, S Kitazawa, M Horio, S Maeda, K Nagasako
• Journal: Human pathology (Hum Pathol) Vol. 23 Issue 6 Pg. 681-5 (Jun 1992) ISSN: 0046-8177 [Print] United States
• PMID: 1592392 (Publication Type: Journal Article)

Chemical References

• Transforming Growth Factor beta
• Epidermal Growth Factor

Topics

• Epidermal Growth Factor (analysis)
• Humans
• Immunoenzyme Techniques
• Neoplasm Invasiveness
• Stomach Neoplasms (chemistry, pathology)
• Transforming Growth Factor beta (analysis)