Association between beta-adrenergic receptor polymorphisms and their G-protein-coupled receptors with body mass index and obesity in women: a report from the NHLBI-sponsored WISE study.
Abstract | OBJECTIVES: The beta-adrenergic receptor (betaAR) genes are candidate genes for obesity because of their roles in energy homeostasis and promotion of lipolysis in human adipose tissue. Objective is to determine the association between obesity and polymorphisms in genes of the beta(1)AR (ADRB1), beta(2)AR (ADRB2), beta(3)AR (ADRB3), Gs protein alpha (GNAS1), to which all three beta-receptors couple and the G protein beta3 subunit (GNB3), to which beta(3)ARs couple. DESIGN: A case-control genetic association study. SUBJECTS: A total of 643 black or white women enrolled in Women's Ischemia Syndrome Evaluation (WISE) study. MEASUREMENTS: Genotypes were determined by PCR with single primer extension. Associations between genotype and body mass index (BMI), waist-to-hip ratio (WHR), waist circumference, and obesity were made. RESULTS: Polymorphisms in the three betaAR genes, GNAS1, and GNB3 were not associated with BMI, WHR, waist circumference, or obesity. Linear and logistic regression analyses found no contribution of either genotype or haplotype with anthropometric measurements or obesity. CONCLUSIONS:
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Authors | S G Terra, S P McGorray, R Wu, D M McNamara, L H Cavallari, J R Walker, M R Wallace, B D Johnson, C N Bairey Merz, G Sopko, C J Pepine, J A Johnson |
Journal | International journal of obesity (2005)
(Int J Obes (Lond))
Vol. 29
Issue 7
Pg. 746-54
(Jul 2005)
ISSN: 0307-0565 [Print] England |
PMID | 15917856
(Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Receptors, Adrenergic, beta
- Receptors, G-Protein-Coupled
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Topics |
- Adipose Tissue
(metabolism)
- Adult
- Aged
- Aged, 80 and over
- Black People
- Body Mass Index
- Cohort Studies
- Female
- Gene Frequency
- Haplotypes
- Humans
- Linkage Disequilibrium
- Logistic Models
- Middle Aged
- Obesity
(ethnology, genetics, metabolism)
- Polymorphism, Genetic
- Receptors, Adrenergic, beta
(genetics)
- Receptors, G-Protein-Coupled
(metabolism)
- White People
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