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Levofloxacin disposition over time in aqueous humor of patients undergoing cataract surgery.

Abstract
The ocular disposition of levofloxacin in patients receiving two 500-mg oral doses 10 h apart before cataract surgery was assessed with the intent of defining drug ocular exposure over time. The mean aqueous humor concentrations persisted above 1.5 mg/liter between 1.5 and 6.0 h after the second dose, with average aqueous-to-plasma ratios ranging between 0.33 and 0.57. This favorable ocular disposition provides support for trials of systemic levofloxacin for prophylaxis of postoperative endophthalmitis in selected patients or as adjunctive therapy for the treatment of this potentially devastating infective complication.
AuthorsFederico Pea, Ettore Ferrari, Federica Pavan, Derri Roman-Pognuz, Francesco Bandello, Mario Furlanut
JournalAntimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 49 Issue 6 Pg. 2554-7 (Jun 2005) ISSN: 0066-4804 [Print] United States
PMID15917572 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Bacterial Agents
  • Levofloxacin
  • Ofloxacin
Topics
  • Aged
  • Aged, 80 and over
  • Anti-Bacterial Agents (administration & dosage, pharmacokinetics)
  • Aqueous Humor (metabolism)
  • Cataract Extraction (adverse effects)
  • Endophthalmitis (prevention & control)
  • Eye (metabolism)
  • Female
  • Humans
  • Levofloxacin
  • Male
  • Middle Aged
  • Ofloxacin (administration & dosage, pharmacokinetics)
  • Time Factors

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