In vitro and in vivo activities of DA-7867, a new oxazolidinone, against aerobic gram-positive bacteria.

Abstract

In vitro and in vivo activities of DA-7867 were assessed against methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, and penicillin-resistant Streptococcus pneumoniae. All isolates were inhibited by DA-7867 at <or=0.78 microg/ml, a four-times-lower concentration than that of inhibition by linezolid. For murine infection models, DA-7867 also exhibited greater efficacy than linezolid against all isolates tested.

• Authors: Eun Jeong Yoon, Yeong Woo Jo, Sung Hak Choi, Tae Ho Lee, Jae Keol Rhee, Moohi Yoo, Mi Ja Shim, Eung Chil Choi
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 49 Issue 6 Pg. 2498-500 (Jun 2005) ISSN: 0066-4804 [Print] United States
• PMID: 15917554 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Acetamides
• Anti-Infective Agents
• DA-7867
• Oxazolidinones
• Linezolid

Topics

• Acetamides (pharmacology, therapeutic use)
• Aerobiosis
• Animals
• Anti-Infective Agents (pharmacology, therapeutic use)
• Drug Resistance, Bacterial
• Gram-Positive Bacterial Infections (drug therapy, microbiology)
• Gram-Positive Cocci (drug effects, growth & development)
• Humans
• Linezolid
• Male
• Mice
• Mice, Inbred ICR
• Microbial Sensitivity Tests
• Oxazolidinones (pharmacology, therapeutic use)