Amino acid transporters ASCT2 and LAT1 in cancer: partners in crime?

Abstract

Relative to other neutral amino acid transporters, the expression levels of ASCT2 and LAT1, are coordinately elevated in a wide spectrum of primary human cancers, suggesting that they are frequently co-opted to support the "tumor metabolome". Each has recently been shown to play important roles in the growth and survival of cancer cell lines, making them potential targets for cancer therapy. The properties and putative relationship of these two amino acid exchangers are discussed in the context of their demonstrated utility in cancer biology, including cellular growth and survival signaling and integrated links to the mammalian target-of-rapamycin (mTOR) kinase.

• Authors: Bryan C Fuchs, Barrie P Bode
• Journal: Seminars in cancer biology (Semin Cancer Biol) Vol. 15 Issue 4 Pg. 254-66 (Aug 2005) ISSN: 1044-579X [Print] England
• PMID: 15916903 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S., Review)

Chemical References

• Amino Acid Transport System ASC
• Large Neutral Amino Acid-Transporter 1
• Minor Histocompatibility Antigens
• SLC1A5 protein, human
• Protein Kinases
• MTOR protein, human
• TOR Serine-Threonine Kinases

Topics

• Amino Acid Transport System ASC (metabolism)
• Biological Transport
• Humans
• Large Neutral Amino Acid-Transporter 1 (metabolism)
• Minor Histocompatibility Antigens
• Neoplasms (metabolism, pathology)
• Protein Kinases (metabolism)
• TOR Serine-Threonine Kinases