Distribution of cysteinyl leukotriene receptor 2 in human traumatic brain injury and brain tumors.

Abstract

AIM:

To determine the distribution of cysteinyl leukotriene receptor 2 (CysLT2), one of the cysteinyl leukotriene receptors, in human brains with traumatic injury and tumors.

METHODS:

Brain specimens were obtained from patients who underwent brain surgery. CysLT2 in brain tissues was examined using immunohistochemical analysis.

RESULTS:

CysLT2 was expressed in the smooth muscle cells (not in the endothelial cells) of arteries and veins. CysLT2 was also expressed in the granulocytes in both vessels and in the brain parenchyma. In addition, CysLT2 was detected in neuron- and glial-appearing cells in either the late stages of traumatic injury or in the area surrounding the tumors. Microvessels regenerated 8 d after trauma and CysLT2 expression was recorded in their endothelial cells.

CONCLUSION:

CysLT2 is distributed in vascular smooth muscle cells and granulocytes, and brain trauma and tumor can induce its expression in vascular endothelial cells and in a number of other cells.

• Authors: Hua Hu, Gao Chen, Jian-min Zhang, Wei-ping Zhang, Lei Zhang, Qiu-fu Ge, Hong-tian Yao, Wei Ding, Zhong Chen, Er-qing Wei
• Journal: Acta pharmacologica Sinica (Acta Pharmacol Sin) Vol. 26 Issue 6 Pg. 685-90 (Jun 2005) ISSN: 1671-4083 [Print] United States
• PMID: 15916734 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Membrane Proteins
• Receptors, Leukotriene
• cysteinyl leukotriene receptor 2

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Astrocytoma (metabolism, pathology)
• Brain (blood supply, metabolism)
• Brain Injuries (metabolism, pathology)
• Brain Neoplasms (metabolism, pathology)
• Endothelial Cells (metabolism)
• Female
• Ganglioglioma (metabolism, pathology)
• Granulocytes (metabolism)
• Humans
• Male
• Membrane Proteins (metabolism)
• Microcirculation (pathology)
• Middle Aged
• Muscle, Smooth, Vascular (pathology)
• Myocytes, Smooth Muscle (metabolism)
• Receptors, Leukotriene (metabolism)