Differential regulation of survivin by p53 contributes to cell cycle dependent apoptosis.

Abstract	Recent studies indicate that cell-cycle checkpoints are tightly correlated with the regulation of apoptosis, in which p53 plays an important role. Our present works show that the expression of E6/E7 oncogenes of human papillomavirus in HeLa cells is inhibited in the presence of anti-tumor reagent tripchlorolide (TC), which results in the up-regulation of p53 in HeLa cells. Interestingly, under the same TC-treatment, the cells at the early S-phase are more susceptible to apoptosis than those at the middle S-phase although p53 protein is stabilized to the same level in both situations. Significant difference is exhibited between the two specified expression profiles. Further analysis demonstrates that anti-apoptotic gene survivin is up-regulated by p53 in the TC-treated middle-S cells, whereas it is down-regulated by p53 in the TC-treated early-S cells. Taken together, the present study indicates that the differential p53-regulated expression of survivin at different stages of the cell cycle results in different cellular outputs under the same apoptosis-inducer.
Authors	Yan Jin, Yong Wei, Lei Xiong, Ying Yang, Jia Rui Wu
Journal	Cell research (Cell Res) Vol. 15 Issue 5 Pg. 361-70 (May 2005) ISSN: 1748-7838 [Electronic] England
PMID	15916722 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Antineoplastic Agents BIRC5 protein, human DNA-Binding Proteins Diterpenes E6 protein, Human papillomavirus type 18 E7 protein, Human papillomavirus type 18 Inhibitor of Apoptosis Proteins Microtubule-Associated Proteins Neoplasm Proteins Oncogene Proteins, Viral Phenanthrenes Survivin Tumor Suppressor Protein p53 tripchlorolide
Topics	Animals Antineoplastic Agents (metabolism) Apoptosis (physiology) CHO Cells Cell Cycle (physiology) Cricetinae Cricetulus DNA-Binding Proteins (genetics, metabolism) Diterpenes (metabolism) Gene Expression Profiling Gene Expression Regulation HeLa Cells Humans Inhibitor of Apoptosis Proteins Microtubule-Associated Proteins (genetics, metabolism) Neoplasm Proteins (genetics, metabolism) Oligonucleotide Array Sequence Analysis Oncogene Proteins, Viral (genetics, metabolism) Phenanthrenes (metabolism) Survivin Tumor Suppressor Protein p53 (genetics, metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!