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Susceptibility of B lymphocytes to adenovirus type 5 infection is dependent upon both coxsackie-adenovirus receptor and alphavbeta5 integrin expression.

Abstract
Human lymphocytes are resistant to genetic modification, particularly from recombinant adenoviruses, thus hampering the analysis of gene function using adenoviral vectors. This study engineered an Epstein-Barr virus-transformed B-lymphoblastoid cell line permissive to adenovirus infection and elucidated key roles for both the coxsackie-adenovirus receptor and alphavbeta5 integrin in mediating entry of adenoviruses into these cells. The work identified a strategy for engineering B cells to become susceptible to adenovirus infection and showed that such a strategy could be useful for the introduction of genes to alter lymphoblastoid-cell gene expression.
AuthorsCiarán Richardson, Paul Brennan, Martin Powell, Stuart Prince, Yun-Hsiang Chen, O Brad Spiller, Martin Rowe
JournalThe Journal of general virology (J Gen Virol) Vol. 86 Issue Pt 6 Pg. 1669-1679 (Jun 2005) ISSN: 0022-1317 [Print] England
PMID15914844 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • CLMP protein, human
  • Coxsackie and Adenovirus Receptor-Like Membrane Protein
  • Integrins
  • Receptors, Virus
  • Receptors, Vitronectin
  • integrin alphaVbeta5
Topics
  • Adenovirus Infections, Human (virology)
  • Adenoviruses, Human (metabolism, physiology)
  • B-Lymphocytes (metabolism, virology)
  • Coxsackie and Adenovirus Receptor-Like Membrane Protein
  • Humans
  • Integrins (metabolism)
  • Receptors, Virus (metabolism)
  • Receptors, Vitronectin (metabolism)
  • Virus Replication

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