Abstract | BACKGROUND: METHODS: RESULTS: Supplementation with cyanocobalamin in daily oral doses of 2.5, 100, 250, 500, and 1000 mug was associated with mean reductions in plasma methylmalonic acid concentrations of 16%, 16%, 23%, 33%, and 33%, respectively. Daily doses of 647 to 1032 mug of cyanocobalamin were associated with 80% to 90% of the estimated maximum reduction in the plasma methylmalonic acid concentration. CONCLUSION: The lowest dose of oral cyanocobalamin required to normalize mild vitamin B(12) deficiency is more than 200 times greater than the recommended dietary allowance, which is approximately 3 mug daily.
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Authors | Simone J P M Eussen, Lisette C P G M de Groot, Robert Clarke, Jörn Schneede, Per M Ueland, Willibrord H L Hoefnagels, Wija A van Staveren |
Journal | Archives of internal medicine
(Arch Intern Med)
Vol. 165
Issue 10
Pg. 1167-72
(May 23 2005)
ISSN: 0003-9926 [Print] United States |
PMID | 15911731
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Transcobalamins
- Homocysteine
- Methylmalonic Acid
- Vitamin B 12
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Topics |
- Administration, Oral
- Aged
- Aged, 80 and over
- Biomarkers
(blood)
- Dietary Supplements
- Dose-Response Relationship, Drug
- Double-Blind Method
- Female
- Follow-Up Studies
- Homocysteine
(blood)
- Humans
- Male
- Methylmalonic Acid
(blood)
- Radioimmunoassay
- Retrospective Studies
- Transcobalamins
(metabolism)
- Treatment Outcome
- Vitamin B 12
(administration & dosage, blood)
- Vitamin B 12 Deficiency
(blood, drug therapy)
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